Synthetic Route of 23680-40-2,Some common heterocyclic compound, 23680-40-2, name is Methyl 3-bromopropiolate, molecular formula is C4H3BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
5-Deuterio-2-(n-pentyl)furan (1-d1) (0.6 mmol), methyl 3-bromopropiolate 2 (0.5 mmol), and toluene (1.5 mL) were added to a two-necked flask, and the mixture was stirred at reflux for 24 h under nitrogen atmosphere. After completion of the initial Diels-Alder reaction, silica gel (150 mg) was added under a flow of nitrogen and the reaction mixture was stirred at reflux for 2 h. After removal of the solvent and filtration through a pad of silica, 1H NMR spectra of products were measured.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3-bromopropiolate, its application will become more common.
Reference:
Article; Sonoda, Motohiro; Ikeda, Ayu; Shinohara, Hiroyuki; Hayagane, Naoya; Ogawa, Akiya; Tanimori, Shinji; Research on Chemical Intermediates; vol. 45; 1; (2019); p. 13 – 21;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics