Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35120-18-4, name is Ethyl 1-bromocyclobutanecarboxylate, This compound has unique chemical properties. The synthetic route is as follows., Safety of Ethyl 1-bromocyclobutanecarboxylate
Cyclobut-1-enecarboxylic acid2,3 Cyclobut-1-enecarboxylic acid was prepared according to the procedure for preparation of 3,3-dimethylcylobutene carboxylic acid as described by Campbell et al. with minor modifications. KOH (6.00 g, 107 mmol) and toluene (90 ml) were mixed and then heated to reflux until the KOH dissolved. Ethyl 1-bromocyclobutanecarboxylate (4.90 g, 23.7 mmol) was added dropwise without heating. The reaction mixture was heated at reflux for 1 h, then cooled to RT. Cold water (60 ml) was added, the aqueous layer was washed with pentane (2*40 ml) and the pH was adjusted to 2.5 with 30% aq H2SO4. The product was then extracted from the aqueous layer with Et2O (4*40 ml) and dried over anhydrous Na2SO4. The Et2O was evaporated to give a yellow oil. The oil was dissolved in pentane (50 ml) and the upper layer was separated from the lower layer. The upper layer was cooled in an acetone-dry ice bath and stirred for 20 min. The resulting precipitate was filtered and dried under vacuum (1.14 g, 49% yield). The dried solid was stored at -20 C. to prevent decomposition. 1H-NMR (400 MHz, CDCl3) delta 10.23 (bs, 1H), 6.94 (t, J=1.2 Hz, 1H), 2.76 (t, J=3.2 Hz, 2H), 2.51 (td, J=3.2 Hz, 1.2 Hz, 2H); 13C-NMR (100 MHz, CDCl3) delta 167.5, 150.1, 138.4, 29.1, 27.5.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 35120-18-4.
Reference:
Patent; The Research Foundation of State University of New York; US2011/212046; (2011); A1;,
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