Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 26759-46-6, name is Methyl 2-amino-4,5-dimethoxybenzoate, A new synthetic method of this compound is introduced below., category: esters-buliding-blocks
To a solution of 2-amino-4,5-dimethoxy-benzoic acid methyl ester 1 (422 mg, 2 mmol) and 3- methylene-cyclobutanecarbonitrile (558 mg, 6 mmol) in 1,4-dioxane (3 mL) was added 4N HC1 in 1,4- dioxane (8 mL). The mixture was stirred at 100 °C overnight. The resulting mixture was cooled to room temperature and poured into chilly NaHC03 solution (20 mL) to give a precipitate. The solid was collected by filtration, washed with water (30 mL) and dried to give a mixture of compound (156) and (157) (440 mg, yield: 72percent). MS: m/z 307.1 (M-H+).
The synthetic route of 26759-46-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; DUKE UNIVERSITY; PINKERTON, Anthony; MALONEY, Patrick; HERSHBERGER, Paul; PEDDIBHOTLA, Satyamaheshwar; HEDRICK, Michael; BARAK, Lawrence; CARON, Marc; WO2014/100501; (2014); A1;,
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