Discovery of 680-65-9

Electric Literature of 680-65-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 680-65-9, name is Diethyl difluoromalonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Electric Literature of 680-65-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 680-65-9, name is Diethyl difluoromalonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A SOLUTION OF COMMERCIALLY AVAILABLE DIETHYL DIFLUOROMALONATE (10.1145 g, 0.0515 mol) in anhydrous methanol (110 mL) was saturated with ammonia (g) at 0 C for 45 min. The resulting mixture was stirred in an ice bath for 3h and monitored by MS (m/z M+H 139). The product was concentrated under reduced pressure to afford desired amide 13-2 as a white powder (7.1027 g, 99%): HR-MS (ES) m/z CALCD FOR C3H4N2F202 (MH+) =139. 0314. Observed: 139.0278.

The synthetic route of Diethyl difluoromalonate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHARMACIA CORPRATION; WO2004/60376; (2004); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics