Synthetic Route of 711-01-3, These common heterocyclic compound, 711-01-3, name is Methyl adamantane-1-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1 compound (10.7 g, 0.055 mmol, 1 equiv) was dissolved in anhydrous THF (150 mL) under argon and was treated with a solution of LiAIH4 (1 M in THF, 69 mL, 69 mmol, 1.25 equiv). After stirring at rt for 1.5 h, the reaction was cooled to 0C and quenched sequentially with H20 (5.1 mL), 15% aq NaOH (5.1 mL), and H20 (10.2 mL). After stirring at rt for 15 min, the slurry was vacuum filtered, and the solids washed with EtOAc (2X100 mL). The filtrate was concentrated by rotary evaporation and the resulting solid purified by flash column chromatography on SILICA GEL (5X15 cm) with 10% ETOAC/CH2CI2. This afforded the Step 2 product as a white solid (8.74 g, 96%).
Statistics shows that Methyl adamantane-1-carboxylate is playing an increasingly important role. we look forward to future research findings about 711-01-3.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2005/12249; (2005); A2;,
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