6279-86-3, name is Triethyl methanetricarboxylate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of Triethyl methanetricarboxylate
To a solution of tert-butyl [2-[1-(2-iodoethyl)cyclohexyl]ethoxy]diphenylsilane (540 mg) and ethyl methane tricarboxylate (727 mg) in N, N-dimethylformamide (5 ML) was added potassium carbonate (575 mg) at room temperature.. The solution was stirred at 110 C for 6 hours, to which water and 3N hydrochloric acid were added.. The solution was extracted with ethyl acetate.. The organic layer was washed in turn with a 1N aqueous sodium hydroxide solution, water and saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure.. The resulting residue was purified by chromatography (silica gel, hexane:ethyl acetate=85:15) to give the title compound (470 mg).1H-NMR (CDCl3) delta: 1.03 (s, 9H), 1.17-1.40 (m, 12H), 1.23 (t, 9H, J=6.8 Hz), 1.60 (t, 2H, J=8.0 Hz), 1.96-2.04 (m, 2H), 3.68 (t, 2H, J=8.0Hz), 4.18 (q, 6H, J=6. 8 Hz), 7.73-7.45 (m, 6H), 7.64-7.70 (m, 4H).
The synthetic route of 6279-86-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Kyorin Pharmaceutical Co., Ltd.; Nisshin Pharma Inc.; EP1443046; (2004); A1;,
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