Related Products of 99548-54-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 99548-54-6, name is Methyl 3-bromo-2-methylbenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a mixture of Compound II (200 mg) and anisole (6.0 mL) were added phenylboronic acid (117 mg), PdCl2(dppf) (64 mg), potassium iodide (435 mg) and potassium carbonate (362 mg). The mixture was stirred at room temperature for 2.5 hours under carbon monoxide (1 atm) atmosphere, and then stirred at 100C overnight. The reaction mixture was diluted with ethyl acetate, and filtered through Celite. The filtrate was washed with brine, and the organic layer was dried over sodium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 100/0 to 85/15) to give Compound III (105 mg).
The synthetic route of Methyl 3-bromo-2-methylbenzoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dainippon Sumitomo Pharma Co., Ltd.; HORIUCHI, Yoshihiro; FUJIWARA, Hiroaki; SUDA, Hitoshi; SASAKI, Izumi; IWATA, Mitsutaka; SAWAMURA, Kiyoto; EP2612848; (2013); A1;,
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