Introduction of a new synthetic route about 154825-97-5

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 154825-97-5 as follows. Application In Synthesis of Methyl 2-(4-bromophenyl)-2,2-dimethylacetate

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 154825-97-5 as follows. Application In Synthesis of Methyl 2-(4-bromophenyl)-2,2-dimethylacetate

Example XExample X.12-(4-Iodo-phenyl)-2-methyl-propionic acid methyl esterTo 0.45 g (1.7 mmol) 2-(4-bromo-phenyl)-2-methyl-propionic acid methyl ester (WO2008/002671) in 1.5 mL 1,4-dioxane are added 34 mg (0.18 mmol) copper(I) iodide, 0.53 g (3.5 mmol) sodium iodide and 0.04 mL (0.35 mmol) N,N’-dimethylethylendiamine under inert gas atmosphere. The mixture is stirred at 110 C. for 12 h. After cooling, the mixture is diluted with EtOAc and washed with 5% ammonia and water. The organic layer is dried over sodium sulphate. The solvent is evaporated to yield the desired product.C11H13IO2 (M=304.12 g/mol)ESI-MS: 305 [M+H]+Rt (HPLC): 2.21 min (method C)

According to the analysis of related databases, 154825-97-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/214782; (2012); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics