Related Products of 53518-15-3, These common heterocyclic compound, 53518-15-3, name is 7-Amino-4-(trifluoromethyl)-2H-chromen-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The commercially available 7-aminocoumarin 1a,b (1.0 eq) was treated with benzoxazin-4-ones 2a-c (1.0 eq) in glacial acetic acid and the reaction was refluxed until the consumption of starting materials (TLC monitoring). The reaction mixture was cooled to r.t. and the obtained precipitate was filtered-off, washed with Et2O (3 * 10 ml) and dried under vacuum to afford the desired products 3a-f.
The synthetic route of 53518-15-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Bozdag, Murat; Alafeefy, Ahmed Mahmoud; Altamimi, Abdul Malik; Vullo, Daniela; Carta, Fabrizio; Supuran, Claudiu T.; Bioorganic and Medicinal Chemistry; vol. 25; 2; (2017); p. 677 – 683;,
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