Synthetic Route of 185312-82-7,Some common heterocyclic compound, 185312-82-7, name is Methyl 4-bromo-2-chlorobenzoate, molecular formula is C8H6BrClO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation Example 80-1 methyl 2-chloro-4-(methylthio)benzoate sodium thiomethoxide (459 mg) was added to a solution of methyl 4-bromo-2-chlorobenzoate (1.25 g) in N,N-dimethylformamide (10 ml) under ice-cooling, and the mixture was stirred for 2 hr. 1N hydrochloric acid was added to the reaction mixture and the resulting product was extracted three times with ether.. The organic layers were combined, washed successively with water and saturated brine, and dried over anhydrous magnesium sulfate.. The solvent was evaporated and the residue was subjected to silica gel column chromatography (hexane/ethyl acetate=10/1) to give the objective compound (835 mg) as a colorless oil. 1H-NMR(CDCl3): 2.49(3H, s), 3.90(3H, s), 7.11(1H, d, J=8 Hz), 7.23(1H, s), 7.78(1H, d, J=8 Hz).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 4-bromo-2-chlorobenzoate, its application will become more common.
Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US6348474; (2002); B1;,
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