Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 107045-28-3, name is tert-Butyl 4-(aminomethyl)benzoate, A new synthetic method of this compound is introduced below., Recommanded Product: tert-Butyl 4-(aminomethyl)benzoate
The compound [3] produced in example 1 (800 mg, 2.14 mmol) was dissolved in anhydrous DMF (20 mL) under nitrogen, to which was added diisopropyl ethyl amine (DIPEA) (1.27 mL, 7.27 mmol) and the amine [10] (700 mg, 2.35 mmol) followed by HATU (1.88 g, 4.93 mmol). This reaction mixture was stirred at 25 C for 24 hours to produce [6]. The contents of the flask were diluted with ethyl acetate. The organic phase (ethyl acetate) was washed with 1 M hydrochloric acid, saturated sodium bicarbonate and water. The ethylacetate layer was then dried over sodium sulfate, which was filtered off. Removal of the ethylacetate solvent provided the crude product [6], which was purified by flash chromatography with 100% EtOAc and 1-2% MeOH / EtOAc to obtain the pure product [6] (680 mg, 57%) as a white solid. iH NMR (300 MHz, DMSO-d6): delta 11.03 (s, lH), 9.82 (s, lH), 8.46 (t, J = 6.0 Hz, lH), 7.82-7.86 (m, 3H), 7.46-7.52 (m, 2H), 7.35 (d, J = 8.3 Hz, 2H), 5.14 (dd, J = 5.0, 13.5 Hz, lH), 4.32-4.38 (m, 4H), 2.86-2.96 (m, iH), 2.56-2.64 (m, 2H), 2.39 (t, J = 7.5 Hz, 2H), 2.25 (t, J = 7.5 Hz, 2H), 1.97-2.05 (m, lH), 1.82-1.92 (m, 2H), 1.53 (s, 9H). APCrj- = 561.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SALADAX BIOMEDICAL INC.; SALAMONE, Salvatore, J.; COURTNEY, Jodi, Blake; SARD, Howard; HEGDE, Vishnumurthy; VOLKOV, Alexander; WO2011/112358; (2011); A1;,
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