Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 294190-18-4, name is Methyl 3-amino-5-chloro-2-methylbenzoate, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 294190-18-4
[0968] tert-Buty 4-{[5-chloro-3-(methoxycarbonyl)-2-methylphenyI]amino}piperidine-l- carboxylate[0969] To a stirred solution of methyl 3-amino-5-chloro-2-methylbenzoate ( 1.40 g, 7.04 mmol) in CH2CI2 (30 mL) and AcOH (2.50 g, 42.2 mmol) was added N-Boc piperidinone (1.96 g, 9.85 mmol) and sodium triacetoxyborohydride (4.40 g, 21 .1 mmol). The reaction mixture was stirred at 23 C for 1 8 hours and then saturated NaHC03 was added and the mixture was separated. The aqueous layer was extracted with CH2CI2 (3 x 20 mL) and the combined organic layers were concentrated in vacuo. The residue was purified by silica gel columnchromatography (Si02 heptane/ethylacetate=10/l to 1 /1 ) to give the titled compound as oil (2.40 g, 89% yield). -NMR (400 MHz, CDC13) 5ppm; 7.09 (s, 1 H), 6.69 (s, 1 H), 4.05(m, 2H), 3.88 (s, 3H), 3.63 (m, 1 H), 3.42 (m, 1 H), 2.97 (m, 2H), 2.23 (s, 3H), 2.05 (m, 2H), 1 .45 (s, 9H), 1 .27 (m, 2H).
According to the analysis of related databases, 294190-18-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; EPIZYME, INC.; EISAI CO., LTD.; KUNTZ, Kevin, Wayne; CHESWORTH, Richard; DUNCAN, Kenneth, William; KEILHACK, Heike; WARHOLIC, Natalie; KLAUS, Christine; ZHENG, Wanjun; WO2012/142513; (2012); A1;,
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