Synthetic Route of 99548-54-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 99548-54-6, name is Methyl 3-bromo-2-methylbenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a flask was added methyl 3-bromo-2-methylbenzoate (2 Ig, 91.7 mmol), potassium hexacyanoferrate (II) trihydrate (9.7g, 22.9 mmol), Na2Ctheta3 (9.7g, 91.7 mmol) and Pd(OAc)2 (102 mg) in N,N-dimethylacetamide (100 mL). The flask’s atmosphere was evacuated and replaced with nitrogen, and the reaction mixture heated at 1200C for 10 hours. The reaction mixture was cooled to room temperature and diluted with ethyl acetate (150 mL). The resultant slurry was filtered and washed thoroughly with ethyl acetate (2 x 50 mL). The combined filtrate was washed with brine and water, dried over Na2SO4 and evaporated under reduced pressure. The residue obtained after the concentration was purified using flash chromatography (ethyl acetate-hexanes (1:9) as the eluent) to provide methyl 3-cyano-2-methylbenzoate (11.2g, 70% yield). 1H NMR spectrum (in DMSO-d6): delta 8.03 (d, J= 8.1 Hz, IH); 7.98 (d, J= 7.9 Hz, IH); 7.49 (t, IH); 3.84 (s, 3H); 2.65 (s, 3H).
The synthetic route of Methyl 3-bromo-2-methylbenzoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; INOTEK PHARMACEUTICALS CORPORATION; WO2008/106619; (2008); A2;,
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