Synthetic Route of 54535-22-7, These common heterocyclic compound, 54535-22-7, name is Diethyl 2-((phenylamino)methylene)malonate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A 1 L three-necked flask fitted with a mechanical stirrer was charged with 2-phenylaminomethylene-malonic acid diethyl ester (26.3 g, 0.100 mol), polyphosphoric acid (270 g) and phosphoryl chloride (750 g). The mixture was heated to 70 C. and stirred for 4 h. The mixture was cooled to room temperature and filtered. The residue was treated with aqueous Na2CO3 solution, filtered, washed with water and dried. 4-Hydroxyquinoline-3-carboxylic acid ethyl ester was obtained as a pale brown solid (15.2 g, 70%). The crude product was used in next step without further purification.
The synthetic route of 54535-22-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Vertex Pharmaceuticals Incorporated; Chu, Cathy; Dhamankar, Varsha; Dokou, Eleni; Haseltine, Eric L.; Moskowitz, Samuel; Robertson, Sarah; Waltz, David; Chen, Weichao George; US2019/240197; (2019); A1;,
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