Adding a certain compound to certain chemical reactions, such as: 4224-69-5, name is Methyl 2-(bromomethyl)acrylate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4224-69-5, Computed Properties of C5H7BrO2
A 250 mL three-necked flask was evacuated with nitrogen to protect it, and the milled magnesium bars (2.06 g, 84.64 mmol) and THF (40 mL) were added in this order.Turn on stirring, heat to 45 ~ 55 C and add a piece of iodine under reflux to turn into a red-brown solution.The compound of formula 1 (9.2 g, 42.32 mmol) was dissolved in 26 mL of tetrahydrofuran,Then slowly add 20 drops to the reaction system,When the reaction system solution has a reddish brown color, it turns into a yellow emulsion until it turns into a white solution.As the reaction proceeds, the reaction system solution will become a clear and transparent liquid.After the addition, the reaction was performed for 0.5 h to obtain a compound of formula 2.; A 500 mL round-bottomed flask was evacuated with nitrogen, and the compound of formula 3 (5.00 g, 27.93 mmol),THF (80 mL), CuI (8.38 mmol, 1.60g) and LiCl (55.86 mmol, 2.37g),The reaction system was placed in an ice-water bath at 0 C.The compound of formula 2 obtained by the reaction was added dropwise to the reaction system. After the addition, the reaction was carried out for 0.5 h, and the reaction was moved to room temperature for 2 h.After the reaction was completed, an appropriate amount of water was added, followed by extraction with ethyl acetate (40 mL × 3) three times. The organic phases were combined, washed with saturated brine, and dried over anhydrous sodium sulfate.Suction filtration, the filtrate was concentrated under reduced pressure, the crude product was separated and purified by silica gel column (eluent: petroleum ether: ethyl acetate = 30: 1)The compound of formula 4 (5.39 g, yield 82%) was obtained as a colorless oily liquid.
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Reference:
Patent; Shanxi Tumor Institute; Yang Xihua; Ou Wentao; (17 pag.)CN110776488; (2020); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics