In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 869-10-3 as follows. Computed Properties of C10H16Br2O4
To a solution of diethyl 2,5-dibromoadipate (36 g, 100 mmol) in N, N-dimethylformamide (150 mL) was added sodium sulfide (11.8 g, 150 mmol) at room temperature and stirred at room temperature 5 hours.Water and ethyl acetate were added to the reaction, the organic phase was separated, washed with saturated brine, dried and concentrated, and then separated by column chromatography (ethyl acetate / petroleum ether = 1/20) to give the title compound (11.6 g, 50%).
According to the analysis of related databases, 869-10-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Beijing Sai Lintai Pharmaceutical Co., Ltd.; Liang Zhi; Liu Zhihua; Dai Yusen; Hu Yuandong; Sun Ying; Huang Yuanyuan; Peng Yong; Kong Fansheng; Luo Hong; Han Yongxin; (76 pag.)CN107474024; (2017); A;,
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