Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 609-12-1, name is Ethyl 2-bromo-3-methylbutanoate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C7H13BrO2
Under a nitrogen atmosphere, 4. 07 g of potassium ethoxide and 150 mL of purified tetrahydrofuran were added to a 250 mL three-necked flask equipped with a refluxing device and 8 g of ethyl 2-cyclopentyl-2-cyanoacetate was added. The reaction was stirred at room temperature (about 25 C). And then slowly added dropwise to a solution of ethyl 2-bromoisovalerate (9. 2 g) in 50 mL of tetrahydrofuran,And the mixture was heated under reflux for 8 hours. The solvent was then removed by evaporation to give a red viscous liquid and a mixture of white solids. Extracted with ether, washed with water, 5% sodium hydrogencarbonate, and then washed with water until the organic phase was neutral. The organic phase was dried over anhydrous magnesium sulphate for 12 h. Filtering, concentrating the solvent to obtain crude product, and then vacuum distillation, the unreacted raw materials and low boiling point of the material evaporated, 2-cyclopentyl-3-isopropyl-2-cyano-succinate 9. 5 g. The mass spectrum and infrared spectrum of the product were consistent with the structure of the target compound.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 609-12-1.
Reference:
Patent; China Petroleum & Chemical Corporation; SINOPECBeijing Research InstituteofChemicalIndustry; XIE, LUNJIA; TIAN, YU; FENG, ZAIXING; ZHAO, SIYUAN; SUN, ZHUFANG; (18 pag.)CN104418770; (2016); B;,
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