Application of 3153-37-5,Some common heterocyclic compound, 3153-37-5, name is Methyl 4-chlorobutyrate, molecular formula is C5H9ClO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of the product from step d (100 mg, 0.406 MMOL), K2CO3 (120 mg, 0.88 MMOL), Kl (cat.) and methyl 4-chlorobutyrate (140 mg, 1.02 MMOL) in acetone (2 ML) is heated at reflux for 8 hours. 1N sodium hydroxide (2 ML) is then added, and the mixture is heated at 60C for 2 hours. The reaction mixture is poured into water, acidified to pH 1 and then extracted with ethyl ether. The organic phase is washed with water and concentrated. Recrystallisation from cyclohexane of the residue obtained gives the expected product (40 mg). m. p. =81C 1H NMR-CDCI3- (PPM) : 0.87 (3H, m); 1.12-1. 43 (6H, m); 1.53 (2H, m); 2.09 (2H, m); 2.37-2. 68 (4H, m); 2.85 (2H, m); 3.23 (2H, m); 3.59 (2H, m); 4.03 (2H, m); 6.99 (1 H, s); 7.40 (1 H, s).
The synthetic route of 3153-37-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK PATENT GMBH; WO2004/63148; (2004); A1;,
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