In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 51760-21-5 as follows. name: Dimethyl 5-bromoisophthalate
In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 51760-21-5 as follows. name: Dimethyl 5-bromoisophthalate
Example 23 Step a 2′-Trifluoromethyl-biphenyl-3.5-dicarboxylic acid dimethyl ester (23a”); An oven-dried vial containinga magnetic stir bar was charged with dimethyl-5-bromo isophthalate (500 mg, 1.83 mmol), Pd(OAc)2 (4 mg, 1.0 mol%), S-Phos (15.0 mg, 2.0 mol%), 2- (trifluoromethyl) -phenyl boronic acid (695 mg, 3.66 mmol, 2 equiv.) and powdered, anhydrous KsPO4(1.16 g, 5.49 mmol, 3 equiv.). The vial was capped with a Teflon septum and then evacuated and backfilled with azote (this sequence was repeated three times). Dry toluene (4.0 mL) was added through the septum via syringe and the resulting mixture was stirred at 100 0C for 24 h. The reaction mixture was then allowed to cool to room temperature, diluted with diethyl ether (20 mL), filtered through a thin pad of silica gel (eluting with EtOAc) and concentrated under reduced pressure. The golden oil obtained which solidified upon standing was used as such. LCMS m/z 356 (M+Na)+, Rf = 0.32 (EtOAc/n-Heptane, 1/1).
According to the analysis of related databases, 51760-21-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MEDIVIR AB; WO2008/119773; (2008); A1;,
Ester – Wikipedia,
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