In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39503-58-7, name is Methyl 5-bromo-2-methoxy-4-methylbenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: esters-buliding-blocks
Amixture of methyl 5-bromo-2-methoxy-4-methylbenzoate (41,100 mg, 0.39 mmol), Zn(CN)2 (31.7 mg, 0.27 mmol), xantphos(2.23 mg, 0.0039 mmol), Pd2(dba)3 (21.2 mg, 0.0232 mmol) andN,N,N’,N’-tetramethylenediamine (8.97 mg, 0.0772 mmol) inanhydrous DMF (1 mL) was placed in a 5 mL tube. Nitrogen wasbubbled through the mixture for 5 min, then the tube was immediatelysealed and heated to 160 C (under microwave irradiations)for 200 s. The mixture was then cooled down to room temperatureand diluted with EtOAc (30 mL). The organic phase was washedwith brine (3*10 mL), dried over Na2SO4, filtered, and concentratedunder reduced pressure. The crude was purified by flash columnchromatography on silica gel (EtOAc in petroleum ether, 0%e50%)to afford the title compound (73 mg, 92%) as a white solid. 1H NMR(400 MHz, CDCl3): delta 8.09 (s, 1H), 6.89 (s, 1H), 3.97 (s, 3H), 3.90 (s,3H), 2.59 (s, 3H). MS m/z 206 [M+H]+.
The synthetic route of 39503-58-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Lovering, Frank; Morgan, Paul; Allais, Christophe; Aulabaugh, Ann; Brodfuehrer, Joanne; Chang, Jeanne; Coe, Jotham; Ding, WeiDong; Dowty, Heather; Fleming, Margaret; Frisbie, Richard; Guzova, Julia; Hepworth, David; Jasti, Jayasankar; Kortum, Steve; Kurumbail, Ravi; Mohan, Shashi; Papaioannou, Nikolaos; Strohbach, Joseph W.; Vincent, Fabien; Lee, Katherine; Zapf, Christoph W.; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 606 – 621;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics