Electric Literature of 7270-63-5,Some common heterocyclic compound, 7270-63-5, name is 5-Diazo-2,2-dimethyl-1,3-dioxane-4,6-dione, molecular formula is C6H6N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of diazo compound 1 (0.5 mmol) and alkynes (1.1 mmol) in toluene (2 mL) was added rhodium(II) pivalate (0.01 mmol). The reaction mixture was stirred at 60C for 0.5-5 h. The solvent was evaporated in rotary evaporator under reduced pressure to give the residue. The residue was purified by flash column chromatography on silica gel to give the product. 4.2.10. 2,4-Bis(3-fluorophenyl)-6H-furo[2,3-b]pyran-6-one (5i). Reaction of 1 (85 mg, 0.5 mmol) and 1-ethynyl-3-fluorobenzene (132 mg, 1.1 mmol) under Rh2(OPiv)4 (6 mg, 0.01 mmol) afforded 5i (69 mg, 43%) as a solid: mp 128-130 C; 1H NMR (300 MHz, CDCl3) delta 7.39-7.37 (3H, m), 7.34-7.27 (3H, m), 7.20-7.18 (1H, m), 6.99-6.96 (1H, m), 6.84 (1H, s), 6.18 (1H, s); 13C NMR (75 MHz, CDCl3) delta 164.6, 161.4, 159.0, 158.9, 152.3, 147.4, 137.0, 136.9, 131.1, 130.7, 123.3, 119.3, 117.9, 115.4, 114.7, 110.7, 105.6, 101.6, 99.4; IR (KBr) 2928, 1761, 1715, 1588, 1437, 1240, 1181, 1076, 926, 784, 692 cm-1; HRMS m/z (M+) calcd for C19H10F2O3: 324.0598. Found: 324.0599.
The synthetic route of 7270-63-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Somai Magar, Krishna Bahadur; Lee, Yong Rok; Kim, Sung Hong; Tetrahedron; vol. 69; 44; (2013); p. 9294 – 9302;,
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