Electric Literature of 4224-69-5, These common heterocyclic compound, 4224-69-5, name is Methyl 2-(bromomethyl)acrylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The solution of aldehyde 8 (13.0 g, 25 mmol) in THF (80mL) was mixed with saturated solution of NH4Cl (100 mL)and Zn dust (1.6 g, 50 mmol) at the room temperature. Themixture was stirred and the methyl 2-(bromomethyl)acrylate (7.2 g, 40 mmol) was added inseveral portions. The mixture was stirred for 1 hour, diluted with diethyl ether (900 mL), washedby brine (2×150 mL) and dried over Na2SO4. The solvents were evaporated and the product waspurified by column chromatography (EtOAc:hexane 1:2) to obtain 9 (13.4 g, 87%) as a colorlessliquid, diastereomeric mixture (~0.43:0.54 labeled as A and B).
Statistics shows that Methyl 2-(bromomethyl)acrylate is playing an increasingly important role. we look forward to future research findings about 4224-69-5.
Reference:
Article; Baranov, Mikhail S.; Kaskova, Zinaida M.; Grit?enko, Roman; Postikova, Svetlana G.; Ivashkin, Pavel E.; Kislukhin, Alexander A.; Moskvin, Dmitrii I.; Mineev, Konstantin S.; Arseniev, Alexander S.; Labas, Yulii A.; Yampolsky, Ilia V.; Synlett; vol. 28; 5; (2017); p. 583 – 588;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics