In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 116419-94-4 as follows. category: esters-buliding-blocks
Method 23; 4-Bromomethyl-3-trifluoromethyl-benzoic acid methyl esterA suspension of 4-methyl-3-trifluoromethyl-benzoic acid methyl ester (Method 22;0.327 g, 1.5 mmol), iV-bromosuccinimide (267 mg, 1.5 mmol) and benzoyl peroxide (0.15 mmol) in CCl4 (10 ml) was heated to reflux for 3 h. The reaction mixture was cooled to25 C, filtered through a pad of silica gel, and washed with DCM. The organics were removed under reduced pressure and the crude product was purified by column chromatography utilizing an ISCO system (hexanes/EtOAc) to give 252 mg (56.5%). NMR: 7.70-8.25 (m,3H), 4.85 (s, 2H)5 3.91 (s, 3H); m/z 297.
According to the analysis of related databases, 116419-94-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/79791; (2006); A1;,
Ester – Wikipedia,
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