Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3196-15-4, name is Methyl 2-bromobutyrate, A new synthetic method of this compound is introduced below., HPLC of Formula: C5H9BrO2
Sodium sulfite (12.61 g, 0.1 mol) and sodium bicarbonate (8.40 g, 0.105 mol) were added to 100 mL of water and 10 mL of tetrahydrofuran and then stirred. When the salts dissolved completely, IX (18.05 g, 0.05 mol) was added and the temperature of 15 C was maintained for 12 h, while stirring. Upon the reaction completion, the precipitated solid was obtained by filtration and the filter cake was directly added to a stirred mixture of 2-bromobutyric acid methyl ester (9.05 g, 0.05 mol) and methanol (200 mL), which was then heated to 60 C. The progress of the reaction was monitored by GC up to complete disappearance of 2-bromobutyric acid methyl ester. The resulting mixture was then cooled to room temperature and the first precipitated solid was removed by filtration. VI was further crystallized from the filtrate. Yield: 18.27 g (85.6 %). Melting point: 47.9-48.9 C.
The synthetic route of 3196-15-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Shi, Yun-Long; Wang, Ling; Qian, Chao; Tao, Ming; Liao, Zu-Tai; Chen, Xin-Zhi; Chemical Papers; vol. 69; 9; (2015); p. 1237 – 1243;,
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