Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 369-26-6, name is Methyl 3-amino-4-fluorobenzoate, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C8H8FNO2
Step 2: Methyl 4-fluoro-3-(imidazo[1 ,2-a]pyridine-3-carboxamido)benzoateA solution of methyl 3-amino-4-fluorobenzoate (5 g, 29.6 mmol) in pyridine (200 ml) was treated with imidazo[1 ,2-a]pyridine-3-carbonyl chloride. HCI (step 1 )(6.43 g, 29.6 mmol) and the mixture was stirred at RT for 2 days. The mixture was poured into water (30 ml) and a small exotherm was observed. After cooling to RT, the resulting precipitate was filtered and dried in a vacuum oven to afford the title compound; LC-MS: Rt 0.81 mins; MS m/z 314.2 {M+H}+; Method 2minl_C_v0031 H NMR (400 MHz, DMSO-d6) delta 10.30 (1 H, s), 9.44 (1 H, d), 8.63 (1 H s), 8.34 (1 H, dd), 7.83 (1 H, m), 7.78 (1 H, d), 7.54 (1 H, m), 7.48 (1 H, m), 7.20 (1 H, t), 3.90 (3H, s)
According to the analysis of related databases, 369-26-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NOVARTIS AG; IRM LLC; BRUCE, Ian; CHAMOIN, Sylvie; COLLINGWOOD, Stephen Paul; FURET, Pascal; FURMINGER, Vikki; LEWIS, Sarah; LOREN, Jon Christopher; MOLTENI, Valentina; SAUNDERS, Alex Michael; SHAW, Duncan; SVIRIDENKO, Lilya; THOMSON, Christopher; YEH, Vince; JANUS, Diana; WEST, Ryan; WO2013/30802; (2013); A1;,
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