The origin of a common compound about Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate

Synthetic Route of 1150566-27-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1150566-27-0, name is Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Synthetic Route of 1150566-27-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1150566-27-0, name is Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate (600 mg, 2.66 mmol) and 2-(trifluoromethyl)pyrrolidine (1g, 7.19 mmol) were heated in a sealed tube at 173 C for 16h. After cooling to room temperature, water (100 mL) was added. The aqueous layer was extracted with ethyl acetate (2 x 100 mL). Combined organic layers were dried, concentrated and product was purified by column chromatography to afford ethyl 6-(2-(trifluoromethyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine-3-carboxylate (270 mg, 30%). MS (ESI) calcd for C14H15F3N4O2 (m/z): 328.1.

The synthetic route of Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GlaxoSmithKline LLC; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.; (583 pag.)EP2768509; (2017); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics