Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 27492-84-8, name is Methyl 4-amino-2-methoxybenzoate, A new synthetic method of this compound is introduced below., Quality Control of Methyl 4-amino-2-methoxybenzoate
Method 2A mixture of methyl 4-amino-2-methoxybenzoate (10.8 g, 59.6 mmol), the product from step(i) above (20.09 g, 54.2 mmol) and potassium carbonate (15 g, 109 mmol) in DMF (300 mL)was degassed with N2 for 10 mm. BrettPhos G3 precatalyst(1 g, 1.103 mmol) was added andthe mixture heated at 85°C for 3 h. The mixture was cooled then partitioned between DCM(500 mL) and water (800 mL). The organic layer was washed with water (500 mL), dried (MgSO4), filtered and evaporated under reduced pressure. The residue was triturated with ether, filtered and dried to afford the sub-title compound (21.7 g) as a grey solid. 1H NMR (400 MHz, DMSO-d6) O 9.38 (s, IH), 9.36 (s, IH), 8.18 (d, IH), 8.14 (d, IH), 7.83 (d,IH), 7.54-7.66 (m, 5H), 7.38 (d, IH), 7.22 (dd, IH), 6.69 (dd, IH), 6.14 (d, IH), 3.74 (s, 3H),3.71 (s, 3H), 1.53 (s, 9H).LCMS m/z 516 (M+H) (ES)
The synthetic route of 27492-84-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED; FYFE, Matthew Colin Thor; (62 pag.)WO2016/51188; (2016); A1;,
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