Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13831-03-3, name is tert-Butyl propiolate, A new synthetic method of this compound is introduced below., SDS of cas: 13831-03-3
(1.0 mmol) of 1- (4′-bromophenyl) -2,2,2-trifluoroethanone (1.0 mmol), t-butyl propiolate (1.0 mmol),t-butylpropiolateAg2CO3(0.05 mmol), KOH (0.1 mmol) and DMA (1 mL) were added to Xu Linke bottles and thereaction was stirredatroom temperature for 24 h. The reaction was followed by TLC.After completion of the reaction, 15 mL of saturated brine was added to quench the reaction, antishall reaction mixture was extracted with dichloromethane (15 mL × 3) the product, the organic phases were combined, and concentrated using a rotary evaporator to give crude productproduct column chromatography to obtain the target The product, eluting with column chromatography, was petroleum ether: ethyl acetate (100: 1) and the product structure wasidentifiedbyNMR and high resolution mass spectrometry.1l isolated yield of 44%, 2l isolated yield of 43%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Shihezi University; Liu Ning; Dai Bin; Wang Lei; (8 pag.)CN106432171; (2017); A;,
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