Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 344-14-9, name is Dimethyl 2-fluoromalonate, A new synthetic method of this compound is introduced below., Recommanded Product: Dimethyl 2-fluoromalonate
Sodium hydride (60% dispersion in mineral oil; 2.93 g, 73.3 mmol) was added to a solution of dimethyl 2-fluoromalonate (10.0 g, 66.6 mmol) in THF (218 mL) with vigorous stirring. After 30 minutes iodomethane (4.56 mL, 73.3 mmol) was added. The reaction was stirred for a further 3 hours. The reaction was quenched with water and then extracted with EtOAc (4*100 mL). The combined organic layers were dried over Na2SO4, filtered, and concentrated under reduced pressure to afford dimethyl 2-fluoro-2-methyl-propanedioate (8.4 g, 77%) as an orange oil. 1H NMR (300 MHz, DMSO-d6, 27 C.) 1.72 (3H, d), 3.77 (6H, s).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; AstraZeneca AB; BARLAAM, Bernard Christophe; O’DONOVAN, Daniel Hillebrand; HUGHES, Samantha Jayne; MOSS, Thomas Andrew; NISSINK, Johannes Wilhelmus Maria; SCOTT, James Stewart; YANG, Bin; (148 pag.)US2018/111931; (2018); A1;,
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