Synthetic Route of 2876-78-0,Some common heterocyclic compound, 2876-78-0, name is Methyl 1-Naphthaleneacetate, molecular formula is C13H12O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Triflic anhydride (16.6 mL, 0.099 mmol) and diphenyl sulfoxide (10.0 g, 49.4 mmol) and methyl 2- (naphthalen-l – yl) acetate (10.9 g, 54.5 mmol) in DCM (100 mL) solution of the It was added dropwise at -78 and stirred for 3 hours.Water was added (50 mL) quenched the reaction slowly, the mixture was slowly heated to room temperature.The layers were separated and the organic layer is required 2M sodium iodide solution (100 mL 10x), and water (3x 100 mL) was concentrated to a rear, viscous oil washed, precipitated the title compound which in MTBE (600 mL) ( 18.7 g, 74%) was obtained as a light brown hygroscopicsolid.
The synthetic route of 2876-78-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Rohm and Haas Electronic Materials LLC; Rabom., Paul J.; (39 pag.)KR2015/35454; (2015); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics