Adding a certain compound to certain chemical reactions, such as: 82782-85-2, name is Methyl 4H-thieno[3,2-b]pyrrole-5-carboxylate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 82782-85-2, name: Methyl 4H-thieno[3,2-b]pyrrole-5-carboxylate
Compounds e4. Dried K2CO3 (0.15 mol), alkylating agent (0.1 mol) and crown-16 (0.5 mmol) were added to the solution of compound e3 (0.1 mol) in DMF (100 ml). The suspension obtained was stirred at 80-90 C. for 4 hours, cooled to room temperature and poured into 10-fold volume of water. The precipitated solid was filtered off, washed with water, dried in the opened air and recrystallized from ethanol. The oily products were extracted three times with methylene chloride, combined extracts were washed with water, dried over MgSO4 and evaporated at reduced pressure. The residue was recrystallized from ethanol. If required, recrystallization was repeated from the proper solvent. The yield of compounds e4 was 30-75%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 4H-thieno[3,2-b]pyrrole-5-carboxylate, and friends who are interested can also refer to it.
Reference:
Patent; ALLA CHEM, LLC; US2011/53915; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics