Application of 90030-48-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 90030-48-1 name is Sodium 3-methoxy-3-oxopropane-1-sulfinate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A solution of 1-(5-(4-chloro-2-fluorophenyl)-2-methyl-7,8-dihydro-[1 ,3,4]thiadiazolo- [2 3^2,3]imidazo[4,5-c]pyridin-6(5H)-yl)-2-((2-chloro-6-iodopyridin-3-yl)oxy)ethanone (150 mg), Cul (135 mg) and sodium 3-methoxy-3-oxopropane-1-sulfinate (124 mg) in DMSO (1.5 mL) was stirred at 130C for 2.5h. Sat. aq. NH4CI (5 mL) was added at rt and the mixture was stirred for 1 h. The mixture was diluted with EA and sat. aq. NaHC03. The layers were separated and the aq. phase was washed twice with EA. The combined org. layers were washed with aq. sat. NaCI, dried over MgS04, filtrated off and evaporated in vacuo. The crude was purified by FC (solvent: DCM/MeOH, 95/5) to afford 107 mg of a beige solid. LC- MS (A): tR = 0.88 min; [M+H]+: 642.49.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Sodium 3-methoxy-3-oxopropane-1-sulfinate, and friends who are interested can also refer to it.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; BUR, Daniel; GRISOSTOMI, Corinna; NAYLER, Oliver; REMEN, Lubos; VERCAUTEREN, Magali; WELFORD, Richard; WO2015/75023; (2015); A1;,
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