Adding a certain compound to certain chemical reactions, such as: 15964-79-1, name is Methyl 2-(3,4-dimethoxyphenyl)acetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15964-79-1, Computed Properties of C11H14O4
To a 250 mL three-necked flask, compound 6a (10 g, 0.048 mol) and 80 mL of tetrahydrofuran were added.Paraformaldehyde (15 g, 0.48 mol), potassium carbonate (20 g, 0.144 mol) were successively added, and reacted at 40 C. for 2 h.After the reaction was completed, the reaction solution was poured into a separatory funnel, 100 ml of water was added, and the mixture was extracted with 150 ml of tetrahydrofuran.The organic layer was collected, dried over anhydrous sodium sulfate, filtered, and the filtrate was evaporated to dryness under reduced pressure to give 9.6 g of compound 5a.Yield 90.0%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-(3,4-dimethoxyphenyl)acetate, and friends who are interested can also refer to it.
Reference:
Patent; Zhejiang Yongning Pharmaceutical Co., Ltd.; Ye Tianjian; Lu Xiuwei; Yu Guangliang; He Si; (11 pag.)CN105153105; (2018); B;,
Ester – Wikipedia,
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