Application of 935273-86-2,Some common heterocyclic compound, 935273-86-2, name is Benzyl 3,3-difluorocyclobutanecarboxylate, molecular formula is C12H12F2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To solution of benzyl 3,3-difluorocyclobutane carboxylate(450 mg, 2.0 mmol) dissolved in ethanol (10 mL), was added Pd/C(10%, 40 mg). The reaction mixture was stirred at room temperature for 10 hours under the atmosphere of hydrogen(15 psi). After TLC showed that the reaction was completed, the solid was filtered out, the filtrate was concentrated under vacuum to give 3,3-difluorocyclobutane carboxylic acid(250 mg, 83.1% yield) as a white solid. MS (ESI) Calcd. for C5H6F2O2 [M+H]+ 137, Found 137.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Benzyl 3,3-difluorocyclobutanecarboxylate, its application will become more common.
Reference:
Patent; Wuxi Fortune Pharmaceutical Co., Ltd; WU, Hao; LI, Peng; MAO, Weiwei; CHEN, Shuhui; WANG, Fei; LI, Jian; (53 pag.)EP3290418; (2018); A1;,
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