Synthetic Route of 39149-80-9, The chemical industry reduces the impact on the environment during synthesis 39149-80-9, name is tert-Butyl 2-bromopropanoate, I believe this compound will play a more active role in future production and life.
To a solution of A-4 (200 mg, 0.68 mmol) in DMF (4 mL) was added tert-butyl 2-bromopropanoate (169.98 mg, 0.81 mmol) and CS2CO3 (441.45 mg, 1.35 mmol). The resulting mixture was stirred at 55 C for 2 hours. Saturated NH4C1 aqueous (20 mL) and EtOAc (20 mL) were added to the reaction mixture. After separation, the organic layer was washed with brine (20 mL x 2), dried over anhydrous Na2SC>4, filtered and concentrated to give the crude product that was purified by flash chromatography on silica gel (EtOAc in PE = 0% to 10% to 20%) to afford A-51 (235 mg, 0.55 mmol) as an oil. 1H NMR (CDCI3, 400MHz) deltaH = 7.53 (d, 2H), 7.33 – 7.28 (m, 4H), 7.13 (s, 1H), 5.05 (q, 1H), 1.75 (d, 3H), 1.44 (s, 9H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 2-bromopropanoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PRAXIS PRECISION MEDICINES , INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; (244 pag.)WO2018/148745; (2018); A1;,
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