Reference of 69812-51-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 69812-51-7, name is Methyl 4-chlorosulfonylbenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
The reactions were carried out in a one-neck round bottomask. The corresponding 2-amino-2-methylpropanoic acid (0.88 g,8.5 mmol) and triethylamine (3.4 g, 34 mmol) were added to avigorously stirred mixture of water (5 mL) at 0C. When solidcompletely dissolved in water, 4-chlorosulfonyl benzoic acidmethyl ester (1 g, 4.3 mmol) was added dropwise over 30 min. Thenthe reaction was stirred at rt for 12 h, the product was extractedwith EtOAc (3 50 mL). Combined organic layers were dried overNa2SO4, concentrated in vacuo. The residue was puried by silicagel column chromatography (DCM/MeOH 30/1) to afford thedesired product. Yellow solid, m.p. 170.2e173.6C.1H NMR(400 MHz, DMSO) d 8.24 (s, 1H), 8.10 (d, J 8.4 Hz, 2H), 7.93 (d,J 8.4 Hz, 2H), 3.88 (s, 3H), 1.28 (s, 6H).13C NMR (100 MHz, DMSO)d 175.5, 165.7, 148.0, 132.9, 130.2, 127.0, 58.4, 53.0, 26.2. HRMS (ESI-TOF) m/z Calcd for C12H15NO6S [MNa]324.0518, found 324.0504.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-chlorosulfonylbenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Liu, Wei; Xu, Xingyu; Zhao, Hongyan; Yan, Xiaoyu; Tetrahedron; vol. 74; 30; (2018); p. 4111 – 4118;,
Ester – Wikipedia,
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