369-26-6, name is Methyl 3-amino-4-fluorobenzoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: Methyl 3-amino-4-fluorobenzoate
POCI3 (44 mu, 0.470 mmol) was added to methyl 3-amino-4-fluorobenzoate (53.0 mg, 0.313 mmol) and 4-ethylbenzoic acid (47.0 mg, 0.313 mmol) in MeCN (2 ml) and the mixture was heated at 100 °C for 30 min. Solvents were evaporated and residue purified by flash chromatography using 10-20percent) EtOAc in hexanes. Yield: 18.5 mg (20percent>); white solid. The amide from above (18.5 mg, 0.061 mmol) and Lawesson’s reagent (32 mg, 0.078 mmol) in toluene (2 ml) was heated at 110 °C for 2 d. Solvent was evaporated and residue purified by flash chromatography using 20-35percent EtOAc in hexanes as eluent. Yield: 7.1 mg (39percent). Hydroxylamine potassium salt in MeOH (ca 1.7 M, 1.5 ml) was added to the ester from above and the mixture was heated at 60 °C for 45 min before quenched with AcOH (0.5 ml). The title compound was isolated by reversed phase chromatography (Kinetex CI 8, 5 muiotaeta, 21.2 x 100 mm, flow 25 ml/min, gradient 0.1percent TFA in water / acetonitrile over 15 minutes). Yield; 5.1 mg (72percent); white solid.
The synthetic route of 369-26-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KANCERA AB; HAMMER, Kristin; JOeNSSON, Mattias; KRUeGER, Lars; (230 pag.)WO2017/108282; (2017); A1;,
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