Reference of 23786-14-3, These common heterocyclic compound, 23786-14-3, name is Methyl 4-methoxyphenylacetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of methyl 2-(4-methoxyphenyl)acetate (10.0 g, 55.49 mmol) in THF (100 mL) at -78 C was added methyl iodide (23.64 g, 166.5 mmol) very slowly. KO?-Bu (18.68 g, 166.5 mmol) was then added portionwise over 30 min and the reaction mixture was stirred at -78 C for 1 h followed by rt for another 1 h. The reaction was quenched by the addition of water (25 mL) and extracted with EtOAc (2 x 250 mL). The organic layer was dried over Na2S04 and concentrated to obtain the title compound (10.46 g, 91%).
The synthetic route of 23786-14-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard; WO2013/19682; (2013); A1;,
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