Reference of 99548-55-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 99548-55-7 as follows.
Methyl 4-bromo-2-methylbenzoate (2.0 g, 8.73 mmol), cyclopropylboronicacid (1.1 g, 13.10 mmol), potassium phosphate (3.7 g, 17.46 mmol), tricyclohexylphosphine (0.245 g, 0.87 mmol) and palladium(II) acetate (0.195 g, 0.87 mmol) were combined in a sealed tube under nitrogen, then toluene (10 mL) and H20 (1 mL) was added in one portion. The reaction mixture was sealed and heated to 120°C for a period of 16 h. The reaction mixture was allowed to cool and diluted with EtOAc and washed with water. The organic extracts were washed with water and brine, dried and concentrated. The crude obtained was purified by column chromatography using 2-5 percent of EtOAc in hexane to afford the titled compound (1.3 g, 81 percent). FontWeight=”Bold” FontSize=”10″ H NMR (400 MHz, DMSO-dg) delta 7.72 (d, J=8.0 Hz, 1H), 7.01-6.97 (m, 2H), 3.78 (s, 3H), 2.50 (s, 3H), 1.92- 1.91 (m, 1H), 1.02-1.00 (m, 2H), 0.75-0.73 (m, 2H); LC/MS: 191 (Mu+1)+
According to the analysis of related databases, 99548-55-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; BORUAH, Anima; CHITTY VENKATA, Srikanth; HOSAHALLI, Subramanya; PANIGRAHI, Sunil Kumar; WO2014/125408; (2014); A2;,
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