Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52787-14-1, name is Methyl 4-(2-methoxy-2-oxoethyl)benzoate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C11H12O4
] the 23.0 NaH(1.2eq) and 600ml of anhydrous THF added into a 4L of reactor, cool down temperature to 0C, control the Temperature between 0 ~ 15 C then slowly dropping 100. 0 g of intermediate B of 300 mL THF solution and after the completion of addition the reaction was continued to stir for 0.5h ~ 1h.when the reaction was slowly cooled to -20 C ~ -15 C then slowly drop wise added 150mL THF solution of 62. 8 g (1. 1 eq.) 3-Bromo-1-propyne,agter the completion of addition slowly raise the temperature, at -20 C ~ -10 C the reaction was stirred for 1h, then at -10 C ~ 0 C the reaction was stirred for 2h and at 0 C ~ 10 C the reaction was stirred for 3h. The reaction was quenched with 400 mL of water and the intermediate C was extracted with ethyl acetate (400 mL X 2). The organic phase was washed with 200 mL of saturated sodium chloride solution, dried over anhydrous magnesium sulfate, concentrated to dryness, stir beating with n-hexane, The filter cake was washed with a small amount of n-hexane to give a white solid C, Weight: 76. 4 g, yield: 64.5%, HPLC content: 95.3%
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 52787-14-1.
Reference:
Patent; SINOPHARM A THINK PHARMACEUTICAL CO LTD; (19 pag.)CN103739604; (2016); B;,
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