In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54535-22-7, name is Diethyl 2-((phenylamino)methylene)malonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 54535-22-7
Step b :4-hydroxyquinoline 3- carboxylic acid ethyl ester A clean and dry I liter round bottom flask, fitted with mechanical stirrer and thermo pocket was charged 2-Phenylaminotnethylene malonic acid diethyl ester (100 g) and Eaton’s reagent (400 ml) at room temperature. The reaction mass was heated to 80-90 C. and maintained under stirring for 4-6 hours at the same temperature. After completion, the reaction mass was cooled to 5-10 C. and was treated with aqueous sodium carbonate solution at 0-10 C. and stirred for 60-90 minutes at the same temperature. The resultant solid was filtered, washed with water (until the water filtrate showed neutral pH) and dried at 45-50 for 6-8 hours to obtain 4-hydroxyquinoline 3-carboxylic acid ethyl ester (70-80 g)
The synthetic route of 54535-22-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Optimus Drugs Private Limited; Desi Reddy, Srinivas Reddy; Rane, Dnyandev Ragho; Velivela, Venkata Srinivasa Rao; (11 pag.)US2017/96397; (2017); A1;,
Ester – Wikipedia,
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