Adding a certain compound to certain chemical reactions, such as: 87808-49-9, name is Methyl 2-bromo-4-methylbenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 87808-49-9, HPLC of Formula: C9H9BrO2
Methyl 2-bromo-4-methylbenzoate (0.0573 g, 0.25 mmol), alpha-methylstyrene (0.065 mL, 0.50 mmol), palladium acetate (0.0056 g, 0.025 mmol),Tris(4-trifluoromethylphenyl)phosphine (0.0233 g, 0.05 mmol), silver carbonate (0.1379 g, 0.5 mmol), p-toluenesulfonic acid monohydrate (0.0048 g, 0.025 mmol), 1,1,1,3 3,3-Hexafluoro-2-propanol (0.5 mL), o-xylene (0.5 mL), stirred uniformly in a clean and dry closed reaction tube, and then heated to 130 C for 12 hours.After completion of the reaction, the reaction tube was cooled to room temperature, and the reaction system was diluted with 30 mL of ethyl acetate and transferred to a 100 mL separatory funnel. 20 mL of a saturated aqueous solution of ammonium chloride was added thereto, shaken, and allowed to stand to remove the aqueous phase of the lower layer. After that, 20 mL of saturated brine was added thereto, and the mixture was shaken, and the mixture was allowed to stand. The lower aqueous layer was removed, the organic phase was dried over anhydrous sodium sulfate, and the solvent was evaporated. =20:1-10:1, v/v) Separate and purify, remove the solvent by rotary distillation, and drain the oil to obtain a colorless oil.The target product was 56.6 mg, yield 90%.
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Reference:
Patent; Shanxi University; Wen Zhenkang; Ge Xiaomin; Liu Yufang; Chao Jianbin; (16 pag.)CN108774206; (2018); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics