Adding a certain compound to certain chemical reactions, such as: 10601-80-6, name is Ethyl 3,3-diethoxypropionate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10601-80-6, Application In Synthesis of Ethyl 3,3-diethoxypropionate
To a 500 ml reaction flask was added 100 g of tetrahydrofuran, 10.0 g (0. 1 mol) of 3-acetoxypropylene,41. 8 g (0.22 mol) of ethyl 3, 3-diethoxypropionate, 5.2 g (30 mmol) of 47% boron trifluoride acetamidine solution,Nitrogen was replaced three times, and the temperature was raised to 60 C for 4 hours (recovery of diethyl ether). After completion of the reaction, the solvent was recovered, cooled to 20 C, and added20 g of water and 60 g of ethyl acetate were added and the layers were extracted with ethyl acetate and extracted three times (20 g each of ethyl acetate)The combined organic phase was dried over 20 g of anhydrous sodium sulfate for 4 hours, filtered and the ethyl acetate was recovered to give 2- ((4R, 6S) -6-acetoxyMethyl-2-ethoxycarbonylmethyl-1,3-dioxan-4-yl) acetate 27. 5 g, 98.9% purity (GC)82. 7%
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Reference:
Patent; XINFA PHARMACEUTICAL CO LTD; QI, YUXIN; LI, XINFA; LU, QIANGSAN; JU, LIZHU; (15 pag.)CN104163808; (2016); B;,
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