Application of 17100-63-9,Some common heterocyclic compound, 17100-63-9, name is Methyl 4-bromo-3-methoxybenzoate, molecular formula is C9H9BrO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of phenol (0.05 mol) (compounds 3, 8, 67, and 97-98), bromo-benzaldehyde (1.05 equiv.) (compounds 1-2, 9-12,48, 56, and 66), potassium carbonate (2 equiv.) and cupric oxide(0.3 equiv.) in pyridine (50 mL) was stirred under reflux for 12 h.The pyridine was distilled off in vacuo and the residue wasextracted with EtOAc (200 mL). The solution was concentrated andthe residue was purified by flash column chromatography (SiO2 orAl2O3), eluting with a hexane-DCM mixture, to yield the pureproduct as a solid in moderate yield.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 4-bromo-3-methoxybenzoate, its application will become more common.
Reference:
Article; Sun, Bin; Li, Lin; Hu, Qing-wen; Zheng, Hong-bo; Tang, Hui; Niu, Huan-min; Yuan, Hui-qing; Lou, Hong-xiang; European Journal of Medicinal Chemistry; vol. 129; (2017); p. 186 – 208;,
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