Reference of 26218-04-2,Some common heterocyclic compound, 26218-04-2, name is 2-Ethylhexyl 4-aminobenzoate, molecular formula is C15H23NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 2, 4-dichloro-6- (l-methyl-lH-pyrazol-5- yl) -1, 3, 5-triazine (0.23 g, 1 mmol) , 2-ethylhexyl 4- aminobenzoate (0.50 g, 2 mmol) and potassium carbonate(0.30 g, 2.17 mmol) in dioxane (15 mL) is heated to 900C for 4 hours following the reaction by TLC. The solvent is evaporated at low pressure, the residue is diluted in methylene chloride and the organic phase is washed with water. The solvent is removed at low pressure and the resulting crude product is purified by silica gel chromatography to yield 2, 4-bis{4- [ (2- ethylhexyloxy) carbonyl]phenylamino}-6- (1-methyl-lH- pyrazol-5-yl) -1, 3, 5-triazine (0.56 g, 0.85 mmol, 85%, thick oil) .1H RMN (300 MHz, DMSO-d6) : delta 0.82-0.94 (m, 12H), 1.23- 1.46 (m, 16H), 1.67 (m, 2H), 4.17 (d, J= 4.4 Hz, 4H), 4.30 (s, 3H), 7.06 (br s, IH), 7.54 (d, J= 1.9 Hz, IH), 7.94 (br s, 8H), 10.29 (br s, 2H) .UV lambdamax= 293 nm epsilon= 59000 M’1 cm”1 (methanol) .
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Ethylhexyl 4-aminobenzoate, its application will become more common.
Reference:
Patent; ISDIN, S.A.; WO2006/64366; (2006); A1;,
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