In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 178312-47-5, name is Ethyl 4,4-difluorocyclohexanecarboxylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C9H14F2O2
To a stirring solution of crude compound 2 (2.8 g, 14.5 mmol) in THF (50 mL) was added LiHMDS (1M in THF) (21.8 mL, 21.8 mmol) at -78 C and stirred for 1 h. To this, BOM- chloride (2.42 mL, 17.4 mmol) was added drop wise at -78 C; warmed to RT and stirred at RT for 4 h. After consumption of the starting material (by TLC), the reaction was quenched with NH4Cl solution (50 mL) and extracted with EtOAc (2 x 100 mL). The combined organic layer dried over Na2SO4 and concentrated to obtain compound 3 (2.5 g, 55%) as colorless liquid. 1H NMR (500 MHz, CDCl3) delta 7.40-7.21 (m, 5H), 4.49 (s, 2H), 4.22-4.09 (m, 2H), 3.52 (s, 1H), 3.45 (s, 1H), 2.33-2.21 (m, 2H), 2.19-1.93 (m, 2H), 1.93-1.77 (m, 2H), 1.63-1.51 (m, 2H), 1.27 (t, J = 7.1 Hz, 3H). (0435) LCMS (m/z): 313.2 [M++1]
The synthetic route of 178312-47-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; APTINYX INC.; KHAN, M, Amin; (134 pag.)WO2018/26763; (2018); A1;,
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