Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 23426-63-3, name is Methyl 2-bromo-2-methylpropanoate, A new synthetic method of this compound is introduced below., Product Details of 23426-63-3
3 g of 5-tert-butyl-2-nitrophenol (15.37 mmol; 1.0 eq) were dissolved in 42 mL of DMF. 15 g of cesium carbonate (46.10 mmol; 3.0 eq) and 5.97 mL of methyl-2-bromo-2-methylpropanoate (46.10 mmol; 3.0 eq) were added and the session medium was stirred at 110 C. for 1 h. After cooling, the medium was diluted in water and the aqueous phase was extracted three times with EtOAc. The organic phases were washed with brine, dried over MgSO4, filtered and concentrated under vacuum, to give 5.11 g of the title compound in the form of a yellow oil. Yld: 100%. 1H NMR (300 MHz, DMSO-d6) deltappm 1.26 (s, 9H) 1.57 (s, 6H) 3.73 (s, 3 H) 6.87 (d, J=1.8 Hz, 1H) 7.23 (dd, J=8.5, 1.8 Hz, 1H) (d, J=8.5 Hz, 1H). LC-MS: m/z (M+H)+: 296.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; INVENTIVA; BOUBIA, Benaissa; MASSARDIER, Christine; GUILLIER, Fabrice; POUPARDIN, Olivia; TALLANDIER, Mireille; AMAUDRUT, Jerome; BONDOUX, Michel; FEENSTRA, Roelof Williem; VAN DONGEN, Maria Johana Petronella; (207 pag.)US2017/66717; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics