These common heterocyclic compound, 154825-97-5, name is Methyl 2-(4-bromophenyl)-2,2-dimethylacetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of Methyl 2-(4-bromophenyl)-2,2-dimethylacetate
Methyl 2-(4-bromophenyl)-2-methylpropanoate (689 mg, 2.68 mmol),(R)-3-oxo hexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxylic acid tert-butyl ester (630 mg, 2.61 mmol),Pd2(dba)3 (180 mg, 0.19 mmol),2-di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl (550 mg, 1.26 mmol),Cs2CO3 (173 mg, 0.53 mmol) and1,4-dioxane (25mL)Add to a 50mL two-neck bottle,The reaction mixture was reacted under nitrogen for 12 h at 90 C.After the reaction was completed, the reaction was cooled to EtOAc. Add EtOAc (75 mL) and water to the filtrate(50 mL), the resulting mixture was shaken and layered. The aqueous phase was extracted with EtOAc (50 mL).Filtration and concentrating the filtrate under reduced pressure, and the obtained residue was purified by silica gel column chromatography (PE/EA (V/V)=1.2/1)The product was a white solid (200mg, 17.88%)
The synthetic route of Methyl 2-(4-bromophenyl)-2,2-dimethylacetate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Liu Xinchang; Ren Qingyun; Yan Guanghua; S ·geerdeman; Zhang Yingjun; (200 pag.)CN109678859; (2019); A;,
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