Related Products of 10601-80-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10601-80-6 as follows.
Tin (II) chloride dihydrate (9.026 g, 40.0 mmol) was added to a solution of 4-bromo-2-nitrobenzaldehyde (2.3 g, 10.0 mmol) and EtOH (40 ml) followed by 3,3-diethoxypropionic acid ethyl ester (4.75 g, 25.0 mmol ). The reaction was heated to 90 oc for4 hr upon the cooling, the reaction mixture was concentrated and the residue was dissolved inEtOAc and quenched with sat. NaHC03. The resulting emulsion was filtered through a pad ofcelite and rinsed well with EtOAc. The remaining aqueous layer was extracted with EtOAcand the combined organic layer were washed with brine, dried over Na2S04 andconcentrated. The crude product was purified by silica gel column chromatography with 10-30% ofEtOAc in hexanes to give ethyl 7-bromoquinoline-3-carboxylate (0.6 g, 21.5%). OH(400 MHz; CDCh) 1.47 (3H, t, J= 8.0 Hz), 4.50 (2H, q, J= 8.0 Hz), 7.72 (1H, t, J= 4.0 Hz),7.80 (1H, s), 8.36 (1H,s), 8.82 (1H, s), 9.45 (1H, s). 8c (100 MHz; CDCh) 14.3, 61.7, 123.5,125.4,126.3, 130.2, 131.1, 138.5, 150.2, 151.0, 165.0.
According to the analysis of related databases, 10601-80-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI; UNIVERSITY OF KANSAS; HE, John Cijiang; LIU, Ruijie; DAS, Bhaskar; XIAO, Wenzhen; LI, Zhengzhe; LEE, Kyung; (32 pag.)WO2018/129274; (2018); A1;,
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