Related Products of 5445-17-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5445-17-0, name is Methyl 2-bromopropanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: Under N2 atmosphere, a solution of complex 1 (68.7 mg, 5 mol%) in THF (3.0 mL), zinc dust (80 mg, 1.2 mmol), diphenyl disulfide (109 mg, 0.5 mmol), and ethyl 2-bromoacetate (184 mg, 1.1 mmol) were added. Then the mixture was stirred for 2 h at room temperature, monitored by thin-layer chromatography (TLC). The resulting reaction mixture was diluted with diethyl ether (10 mL x 3), filtered, and evaporated, and then the residue was subjected to column chromatography using petroleum ether:ethyl acetate as eluent (30:1) to afford the pure product 6a.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-bromopropanoate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Wang, Lingxiao; Qiao, Jie; Wei, Jiancong; Liang, Zhiwu; Xu, Xinhua; Li, Ningbo; Tetrahedron; vol. 76; 4; (2020);,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics